Toxoplasmosis: serological studies on patients with chorio-retinitis in Nigeria.
نویسندگان
چکیده
AN opportunity presented itself in September and October, 1958, to observe African patients with chorio-retinitis in Kano, Nigeria. Although it was not possible to carry out detailed studies on these patients, blood sera were taken and tested for antibodies to Toxoplasma, a protozoan parasite. The results of these tests are of interest. Wolf, Cowen, and Paige (1938) established toxoplasmosis as a human disease. Severe encephalomyelitis and bilateral chorio-retinitis were found in the patient whom they describe. The ocular pathology of toxoplasmosis was described by Wilder (1925). Jacobs, Fair, and Bickerton (1954) isolated and cultured Toxoplasma from the eye. Our knowledge of ocular toxoplasmosis was summarized in the XIV Jackson Memorial Lecture by Hogan (1958). Antibody to Toxoplasma can be demonstrated in the serum of an affected individual with the methylene blue dye method as described by Sabin and Feldman (1948). Up to the present time the reaction has proved to, be a specific one. In the absence of other known causes of chorio-retinitis, the finding of a high titre in the serum by this test suggests that ocular toxoplasmosis may be present. Feldman and Miller (1956) tested ten human populations in a serological study of toxoplasmosis. The methylene blue dye test was used and only titres of 1: 16 or above were considered positive. There were no positive sera in the Eskimo population. Various city populations in the United States showed from 17 to 35 per cent. positive sera for toxoplasmosis. The sera from the Tahiti population were positive in 68 per cent.
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 44 شماره
صفحات -
تاریخ انتشار 1960